Protein Modification Reagents
Medchemexpress LLC Ald-ph-amido-peg4-c2-acid | 1309460-27-2 | 99.1% | 397.42 | C19H27NO8 | 250 MG
Ald-Ph-amido-PEG4-C2-acid is a noncleavable polyethylene glycol (PEG4) linker intended for use in antibody-drug conjugate (ADC) research. It provides a stable, non-cleavable connection between an antibody and a payload, and is supplied at high purity to support reproducible bioconjugation.
- Noncleavable PEG4 linker suitable for ADC development.
- Terminal carboxylic acid enables amide coupling to payloads.
- Benzaldehyde moiety enables selective conjugation to hydrazide or aminooxy groups.
- High purity supports reproducible conjugation results.
- Molecular weight 397.42 g/mol and formula C19H27NO8.
Medchemexpress LLC Amino-PEG4-C2-SH (hydrochloride) | 2762393-21-3 | >95.0% | 289.82 | 50 MG
Thiol-PEG4-NH2 hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This linker is crucial as PROTACs contain two different ligands connected by such a linker; one targets an E3 ubiquitin ligase and the other targets the protein of interest. PROTACs leverage the intracellular ubiquitin-proteeasome system to selectively degrade target proteins.
- Peg-based protac linker.
- Can be used in the synthesis of protacs.
- Appearance: liquid.
- Color: colorless to light yellow.
- Shipping at room temperature in continental US; may vary elsewhere.
- Storage at -20°C, protect from light, stored under nitrogen.
- For solvent solutions: store at -80°C for 6 months or -20°C for 1 month (protect from light, stored under nitrogen).
Medchemexpress LLC DOTA-PEG5-amine | 98.0% | 666.76 | 100 MG
DOTA-PEG5-amine is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These compounds leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins and are intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Composed of two distinct ligands joined by a linker
- One ligand targets an E3 ubiquitin ligase
- Other ligand targets a specific protein
- Leverages the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Sigma Aldrich Fine Chemicals Biosciences Collagenase from Clostridium histolyticum | 9001-12-1 | MFCD00130830 | 1g
Collagenase from Clostridium histolyticumPurity: MW: | 9001-12-1 | MFCD00130830 | 1g
Medchemexpress LLC Amino-PEG6-amido-bis-PEG5-N3 | 1147.31 | C48H94N10O21 | 25 MG
A cleavable, PEG-based linker containing an azide functional group and a terminal amino group for bioconjugation. Designed as an 11-unit PEG spacer, it provides hydrophilicity and reactive handles for click chemistry and antibody-drug conjugate synthesis.
- Cleavable 11-unit PEG linker providing hydrophilic spacer.
- Contains an azide group for copper-catalyzed and strain-promoted click reactions.
- Terminal amino group enables further conjugation chemistry.
- Suitable for antibody-drug conjugate and bioconjugation applications.
- Available in small lab pack sizes for research use.
Medchemexpress LLC Dbco-PEG4-VA-PBD | 2241644-09-5 | 99.7% | 1430.60 | C80H87N9O16 | 1 MG
DBCO-PEG4-VA-PBD is a drug-linker conjugate intended for antibody-drug conjugate (ADC) conjugation workflows. The molecule features a DBCO reactive group for strain-promoted alkyne-azide cycloaddition (SPAAC), a PEG4 spacer, a valine-alanine protease-cleavable linker, and a pyrrolobenzodiazepine (PBD) cytotoxic payload. Supplied as a solid for research use.
- Contains DBCO group for SPAAC click chemistry
- Includes PEG4 spacer for improved solubility
- Valine-alanine cleavable linker enables intracellular payload release
- PBD payload for potent cytotoxic activity
- Supplied as 1 mg solid; purity reported ~99.7%
- Store at -80°C under nitrogen; shipped on dry ice
Medchemexpress LLC N-(2-(4-(3,5-Dioxo-1,2,4-triazolidin-4-yl)-2-methoxyphenoxy)ethyl)-4,7,10,13-tetraoxahexadec-ynamide | 99.3% | 508.52 g/mol | C23H32N4O9 | 50 MG
PTAD-PEG4-alkyne is a cleavable four-unit polyethylene glycol linker containing a PTAD moiety and a terminal alkyne. It is intended for bioconjugation and antibody-drug conjugate synthesis, enabling tyrosine-selective conjugation and copper-catalyzed azide-alkyne cycloaddition.
- Cleavable PEG4 linker enabling controlled release
- PTAD moiety for tyrosine-selective conjugation
- Terminal alkyne compatible with CuAAC click chemistry
- High purity (99.3%) suitable for research use
- Soluble in DMSO (125 mg/mL); store powder at -20°C
Medchemexpress LLC 3,6,9,12-tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate) | 875770-32-4 | 99.3% | 386.46 | C18H26O7S | 250 MG
Propargyl-PEG4-Tos is a PEG-based linker used as an alkyne click-chemistry reagent and cleavable linker for PROTAC and antibody-drug conjugate synthesis. It provides a hydrophilic PEG4 spacer to improve solubility and enable CuAAC functionalization.
- Click chemistry alkyne for copper-catalyzed azide-alkyne cycloaddition
- Cleavable ADC and PROTAC linker functionality
- PEG4 spacer increases hydrophilicity and solubility
- Confirmed identity by 1H NMR and LCMS
- High purity (HPLC 99.3%)
![Medchemexpress LLC Ethanol, 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]-, 1-(4-methylbenzenesulfonate) | 236754-49-7 | 98.5% | 417.48 g/mol | C17H27N3O7S | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204060.png-250.jpg)
Medchemexpress LLC Ethanol, 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]-, 1-(4-methylbenzenesulfonate) | 236754-49-7 | 98.5% | 417.48 g/mol | C17H27N3O7S | 50 MG
Azide-PEG5-Tos is an azide-functionalized polyethylene glycol linker (PEG length = 5 units) with a tosylate leaving group, used for bioconjugation and assembly of antibody-drug conjugates. It enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions to attach payloads to alkyne-bearing molecules.
- Contains an azide moiety for click chemistry conjugations.
- Peg5 spacer provides hydrophilicity and flexibility.
- Tosylate group serves as a reactive leaving group for functionalization.
- High purity suitable for research applications.
- Soluble in DMSO at ≥100 mg/mL for convenient stock solutions.